Formulation and iritaso test of ethanol extract gel of kersen bark (muntingia calabura l.)
Keywords:
Gel, Irritation, Kersen bark, Physical propertiesAbstract
Skin disease is an infection of microorganisms in the tissue. If not treated properly, it causes poor health. In developing countries, natural ingredients are used to treat skin problems such as cherry bark because it contains flavonoids, saponins, polyphenols and tannins in gel preparations. The purpose of this study was to test the physical properties and irritation of ethanol extract gel preparations of cherry bark (Muntingia calabura L.). Cherry bark was extracted by maceration method for 3 days using 70% ethanol solvent, then formulated with gel material made with extract concentrations F1 (2.5%), F2 (5%) and F3 (7.5%). The results of the physical properties test of all gel preparations met the requirements, namely dispersion diameter 3-7 cm, adhesion> 1 second, pH value according to skin pH, namely 4.5-7.5 and viscosity 2000-50,000 Cps. The results of irritation tests of all in vivo gel preparations with rabbits showed no erythema or edema after treatment for 24, 48 and 72 hours, so the gel preparations were considered safe and did not cause irritation. It can be concluded that all gel preparations of ethanol extract of cherry bark (Muntingia calabura L.) meet the standards for physical properties and irritation tests.
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