The Effect of Green Betel Leaves Extract Concentration in Hydrogel Acne Patch from Breadfruit Starch on the Antibacterial Activity of S. Aureus and P. Acnes
Keywords:
Hydrogel Acne Patch, Green Betel Leaf Extract, Breadfruit StarchAbstract
Betel leaf (Piper betle L.) is a natural antibacterial source, the leaves contain phenolic compounds. Acne patch is a patch that covers acne and prevents bacterial contamination. The acne patch in this study was made from natural breadfruit starch polymer (Artocarpus altilis) combined with betel leaves. The purpose of this study is to determine the physical quality and the effect of green betel leaf extract concentration acnes in hydrogel acne patch preparations made from breadfruit starch on the antibacterial activity of Staphylococcus aureus and Propionibacterium. The antibacterial test method used in this study is the disc diffusion method. The results of the physical quality test of all acne patch formulas meet the requirements. The strongest antibacterial activity was found in the formula containing 125% extract, with an inhibition zone of 17 mm against S. aureus and 32,02 mm against P. acnes. The data analysis using One Way Anava, the yield of p-value of 0.000 (<0.005), indicating that of the green betel leaf extract concentration variation have an effect on the antibacterial activity against S. aureus with a strong category and P. acnes with a very strong category. The highest concentration of green betle leaf extract was significantly increase the antibacterian activity of bradfruit acne patch
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